a Integrated Cancer Registry of Catania-Messina-Siracusa-Enna , Catania , Italy. b Department of Medical, Surgical Sciences, and Advanced Technologies "G.F. Ingrassia," Section of Hygiene and Preventive Medicine, University of Catania , Catania , Italy. c Department of Environmental Health , Environmental & Occupational Medicine & Epidemiology, Harvard TH Chan School of Public Health , Boston , Massachusetts , USA. d St. Elizabeth's Medical Center , Tufts University School of Medicine , Boston , Massachusetts , USA. e Department of Epidemiology and Population Studies , Jagiellonian University Medical College , Krakow , Poland. f Department of Food Science , "Federico II" University Medical School , Naples , Italy. g Department of Biomedical and Biotechnological Sciences, Section of Pharmacology and Biochemistry , University of Catania , Catania , Italy. h The Cambridge Health Alliance, Harvard Medical School , Cambridge , Massachusetts , USA.